Tag: beta-lactam allergy

Drug vs Food Allergy: Immediate & Delayed Reactions

drugallergydetective.com
Infographic comparing drug vs food allergy: immediate (anaphylaxis) and delayed reactions; SJS/TEN uncommon with food.

Drug vs Food Allergy: Why Medications Can Cause Both Immediate and Delayed Reactions — While Foods Uncommonly Cause Severe Delayed Reactions This article is for educational purposes only. Always consult healthcare providers for personalized medical advice. Patients often ask:“Why can medications cause both rapid allergic reactions like hives or anaphylaxis and dangerous delayed reactions such as Stevens–Johnson Syndrome (SJS) or Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), while food allergies almost always appear immediately?” The difference lies in how the immune system processes drugs versus foods — and in…

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Beyond the Surface: Rethinking Rechallenge in Suspected Drug-Induced SSLR and Serum Sickness

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Serum sickness or SSLR

IntroductionDrug-induced serum sickness-like reactions (SSLR) are a complex and often confusing condition for both patients and healthcare providers. These reactions, usually triggered by medications like beta-lactam antibiotics, can cause rash, fever, and joint pain. While SSLRs are generally thought to be milder than true serum sickness, which is caused by immune complexes circulating in the blood, the two conditions can look very similar. The real challenge? In most cases, we rely on patient history alone to make the distinction, and that can be dangerously misleading. The Diagnostic Dilemma: SSLR vs.…

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When and How to Perform Drug Provocation Tests in Drug Hypersensitivity: Timing Matters

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Introduction Drug provocation test timing plays a critical role in evaluating suspected drug allergies. Drug provocation testing (DPT), also known as a drug challenge, remains the gold standard for confirming or ruling out drug hypersensitivity. However, success depends heavily on understanding how soon after drug exposure symptoms appear. By tailoring the timing and protocol of DPT based on the type of reaction—immediate, delayed, or severe—clinicians can improve diagnostic accuracy and minimize risk. This post outlines practical strategies, guideline updates, and real-world challenges that affect how and when drug provocation tests…

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