Understanding Aspirin and NSAID Hypersensitivity: Symptoms, Diagnosis, and Management

Introduction to Aspirin (ASA) and Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Aspirin (ASA) and Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are among the most widely utilized medications in the world, renowned for their efficacy in alleviating pain, reducing inflammation, and lowering fever. Aspirin, extensively studied since its introduction in the late 19th century, is also acclaimed for its cardiovascular benefits, particularly in preventing heart attacks and strokes. NSAIDs, which include ibuprofen, naproxen, and diclofenac, offer similar therapeutic effects and are indispensable in managing a range of conditions from acute injuries to long-term issues like…

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Welcome to Drug Allergy Detective: Your Guide to Drug Allergy Mastery

Unsure about managing drug allergies? Learn effective strategies for communication, avoidance, and specialist care.

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New Sequential Patch Testing for Fixed Drug Eruption (FDE) Diagnosis

Background Fixed drug eruption (FDE) is a cutaneous adverse drug reaction characterized by erythematous plaques or blisters that recur at the same site upon re-exposure to the causative drug. It can leave residual pigmentation and, in severe cases, may present as generalized bullous fixed drug reaction (GBFDE). Objective The study aimed to evaluate the sensitivity of a standardized allergy workup for diagnosing the cause of FDE, with an emphasis on in situ repeated open application tests (ROATs). Methods A retrospective multicenter study analyzed the allergy workup practices for FDE diagnosis…

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