🧠 STAT1 Gain-of-Function vs. STAT3 Loss-of-Function: Understanding Opposite Immune Dysregulation

A humorous cartoon showing the immune system as a see-saw — on one side, overactive red immune cells labeled “STAT1 GOF: Brake Stuck On,” and on the other, sleepy blue immune cells labeled “STAT3 LOF: Accelerator Broken.” A tiny medicine bottle labeled “JAK Inhibitor” tries to balance them.

Educational Content Disclaimer This article provides educational information about rare immunodeficiency disorders. It is not medical advice and should not replace consultation with qualified healthcare providers. Individual presentations vary, and management should be personalized under medical supervision. 🔗 Why This Matters for Drug Allergy Detective At Drug Allergy Detective, we focus on helping you understand drug allergies and hypersensitivity reactions. But to truly understand why certain people react to medications differently, we need to explore the immune system’s foundation. This article explores two rare genetic conditions that represent opposite extremes…

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