Tag: fixed drug eruption

ROAT Patch Testing in SCARs: Is It Time to Reconsider?

drugallergydetective.com
Illustration symbolizing drug allergy testing with ROAT in severe cutaneous adverse reactions (SCARs) such as DRESS, AGEP, and FDE

Introduction Severe cutaneous adverse reactions (SCARs) — such as DRESS, AGEP, and SJS/TEN — are among the most serious drug hypersensitivity syndromes.The traditional approach is simple: avoid all suspected drugs indefinitely. But this blanket avoidance often creates real-world problems: This raises an important question:👉 Is it time to reconsider the role of patch testing — and even the Repeated Open Application Test (ROAT) — in managing SCARs? Why ROAT Is Feared in SCARs The Repeated Open Application Test (ROAT) is a simple diagnostic tool in delayed hypersensitivity: Concerns in SCARs:…

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When and How to Perform Drug Provocation Tests in Drug Hypersensitivity: Timing Matters

drugallergydetective.com

Introduction Drug provocation test timing plays a critical role in evaluating suspected drug allergies. Drug provocation testing (DPT), also known as a drug challenge, remains the gold standard for confirming or ruling out drug hypersensitivity. However, success depends heavily on understanding how soon after drug exposure symptoms appear. By tailoring the timing and protocol of DPT based on the type of reaction—immediate, delayed, or severe—clinicians can improve diagnostic accuracy and minimize risk. This post outlines practical strategies, guideline updates, and real-world challenges that affect how and when drug provocation tests…

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