When and How to Perform Drug Provocation Tests in Drug Hypersensitivity: Timing Matters

Introduction Drug provocation test timing plays a critical role in evaluating suspected drug allergies. Drug provocation testing (DPT), also known as a drug challenge, remains the gold standard for confirming or ruling out drug hypersensitivity. However, success depends heavily on understanding how soon after drug exposure symptoms appear. By tailoring the timing and protocol of DPT based on the type of reaction—immediate, delayed, or severe—clinicians can improve diagnostic accuracy and minimize risk. This post outlines practical strategies, guideline updates, and real-world challenges that affect how and when drug provocation tests…

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Understanding Aspirin and NSAID Hypersensitivity: Symptoms, Diagnosis, and Management

Introduction to Aspirin (ASA) and Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Aspirin (ASA) and Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are among the most widely utilized medications in the world, renowned for their efficacy in alleviating pain, reducing inflammation, and lowering fever. Aspirin, extensively studied since its introduction in the late 19th century, is also acclaimed for its cardiovascular benefits, particularly in preventing heart attacks and strokes. NSAIDs, which include ibuprofen, naproxen, and diclofenac, offer similar therapeutic effects and are indispensable in managing a range of conditions from acute injuries to long-term issues like…

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